Study confirms insulin dysregulation status cannot be predicted from physical observation alone - Veterinary Practice
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Study confirms insulin dysregulation status cannot be predicted from physical observation alone

A new study has concluded that observation of body condition alone is not sufficient to determine the insulin dysregulation status of equids


Vet treating horse
Fxquadro –

Insulin dysregulation (ID) status in ponies cannot be determined solely by observation of body condition concluded a new study, published online last month in association with the Spillers brand.

The study results highlight that ID and the associated increased risk of laminitis may occur in ponies across a wide range of body conditions, ages and levels of exercise, not just in those that are overweight.

The study also showed that ID was less common in ponies that undertook more exercise, including low-intensity exercise.

“This work confirms that while body condition is a useful indicator, we can’t simply assume that ponies with obvious physically apparent attributes such as excess weight are the only group likely to have ID,” said Sarah Nelson, product manager at Mars Horsecare.

“We must consider multiple variables when targeting ponies for ID screening, in order not to miss those potentially at increased risk of laminitis, who may have a ‘healthy’ body condition score.

“The association with even low-level exercise is also an important practical management message for horse owners.”

In the study, the concentration of insulin was measured in the blood of ponies before and sixty minutes after they were orally given a sugar syrup (an oral sugar test (OST)).

An association between ID and laminitis is well-established and early detection of ID is likely to be useful in helping to prevent the disease.

The ID study, carried out by Edd Knowles and colleagues at the Royal Veterinary College, London, and entitled “Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies”, was conducted in collaboration with the makers of Spillers, via the Waltham Equine Studies Group. 

A total of 1,763 OSTs were taken from 367 non-laminitic ponies over four years.

The ponies were visited and tested in the Spring and Autumn unless they developed laminitis.

Various physical parameters were recorded at the time of each OST, including weight, height, body length, neck length, heart girth, belly girth, body condition score and cresty neck score.

Owners/carers were asked to complete a questionnaire concerning the specific characteristics, diet, management, duration and intensity of exercise and health for each pony at each visit.

Serum insulin concentration at 60 min (InsulinT60) during an OST, in the first paper from this work has been shown to be an indicator of future laminitis risk.

The ID study concluded that associations between InsulinT60 and physical and owner-reported variables were limited; season, owner-reported and physical features only explained 10 to 27 percent of the differences in InsulinT60 risk status in the study population.

The findings support previous work that suggested body condition scoring alone was not sufficient to determine insulin dysregulation (ID) status and emphasises the value of using an oral sugar test to screen for ID status.

The lead author Edd Knowles stated in the paper: “Our work has shown that while physical and owner-reported features can be used to identify ponies with a higher risk of ID, veterinarians should not limit testing for ID to ponies in which these risk factors are present.

“Doing so would miss identifying ponies at moderate to high risk of laminitis.” 

The study on ID also indicates that relatively small increments in equine exercise routines may be beneficial.

Eighteen percent of samples from ponies that were reported to do no trotting exercise were in the high-risk InsulinT60 category compared with only 9 percent of samples from those reported to undertake one to two hours of trotting per week.

This finding supports earlier research, conducted in collaboration with the Spillers brand, via the Waltham Equine Studies Group, on the benefits of low intensity exercise.

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